EGFR INHERIT Study
Lung cancer in never-smokers is the 7th most common malignancy worldwide. Environmental and inherited causes in never-smokers remain uncertain, as well as in other populations without an identifiable risk factor.
Lung cancer in never-smokers has recently been found identifiable in family members carrying inherited EGFR gene mutations, called T790M. Understanding underlying biology in high-risk families will provide insight into why lung cancer occurs in never-smokers and others; however, such families have been too rare to study systematically.
INHERIT launched in early December 2012. ALCMI is coordinating tissue collection/analysis and CT-scan banking. Patients with T790M mutation tumors are being tested for underlying inherited T790M mutations and family members are also being recruited. Creating a registry of high-risk families is laying the groundwork for subsequent lung cancer screening and prevention research, irrespective of smoking history.
THIS STUDY IS NOW CLOSED TO ENROLLMENT.
